A total of four innovative Thuringian companies have made it into the 2021 renowned and annually eagerly awaited ranking of Passion4Business GmbH, which has been selecting Germany‘s TOP 50 start-ups since 2016. Pramomolecular, Tediro, Polytives and Robust AO, Thuringia’s award winners, represent a broad spectrum ranging from biotechnology to Industry 4.0 and automation applications to intelligent solutions in medical technology and plastics innovation. The Pramomolecular team from Gera and Berlin ranked fifth with a unique approach to muting cancer proteins in the pancreas and lungs. Robust AO from Jena took 35th place with its idea of increasing resource efficiency by industrially applying adaptive optics for high-power lasers. The startup was spun off from the Fraunhofer Institute for Applied Optics and Precision Engineering (IOF) and has already received the ThEx Award. Tediro came in 41st with its intelligent mobile robots, which can be used primarily in medical diagnostics and treatment in the future and can thus effectively support medical personnel and reduce their workloads. Polytives, a startup founded in Jena in 2020, develops products and solutions to optimize plastics and support recycling. This Thuringian company landed in 44th place in the ranking. (gro)