The researchers, working with their teams, have developed a technology that uses high-resolution fluorescence microscopy to examine living objects without disturbing them with light. To achieve this, they built on an existing technology known as lattice light-sheet microscopy, adding innovative optical elements. They also devised a way to make the complex system easy to use and enabled the broad use of common specimen holders. It opens up entirely new avenues for observing and better understanding cellular processes – both in basic research and in the search for new diagnostic methods or novel drugs to target many diseases. In short, Jena is once again living up to its name as a high-tech hub of the optical industry. (gro)